August 18, 2022

Wearable brain imaging system installed in Toronto for autism research

A wearable brain imaging system developed by Hub researchers through the recently launched spin-out company Cerca Magnetics has been installed at the Hospital for Sick Children (SickKids) in Toronto for ground-breaking research into autism.

This new type of brain scanner, which deploys quantum enabled sensors to measure magnetic fields above the scalp (a process termed magnetoencephalography (MEG)) is being used by researchers in Toronto to scan children who have been identified as having a higher likelihood of developing autism due to siblings having the neurodevelopmental disorder.

World renowned neuroscientist Dr Margot Taylor is leading the Canadian study that will scan the volunteer children from age 12 months onwards on a regular basis and track the development of brain function, looking for differences between those who do or do not develop autism.

“Being an initial site for the Cerca OPM-MEG research system is incredible. For the Cerca team to have delivered the system on-time and with the achieved sensitivity and spatial accuracy, even in our busy city centre location and with the on-going challenges of travel during the pandemic, was truly excellent. We are very excited to be starting the longitudinal research study of brain function in the young siblings of children with autism and toddlers with autism. The Cerca OPM-MEG is essential for this cutting-edge research that was simply not previously possible.”

Dr Margot Taylor, Director of Functional Neuroimaging, Department of Diagnostic Imaging

The installation in Canada was headed up by Dr Ryan Hill, who was the first person to scan toddlers using this new quantum enabled device. In late July this year, he took on the challenge of installing the Toronto system, a job made significantly more difficult by the COVID-19 pandemic.

“At the University of Nottingham we are fortunate to have an environment relatively free from magnetic interference, but this is not the case for many institutions around the world (such as Sick Kids), where busy traffic, building work, metro systems, and other infrastructure in a busy city create a lot of magnetic interference. Thanks to the help and collaboration of the team at Sick Kids during the development of our system, we have been able to mitigate these problems, and successfully acquire high quality brain imaging data in young children and adults alike, including participants with dental wires that could not be scanned in traditional systems.”

Dr Ryan Hill, Hub researcher at the University of Nottingham

Whilst other MEG scanners exist, the Cerca system is unique since it is the only “wearable” MEG system where patients can move freely during the scan. It adapts to different head sizes, making it ideal for scanning children. It also offers considerably higher sensitivity and spatial specificity compared to the current state of the art MEG systems. And all of this is achieved at lower cost compared to conventional systems.

“It is incredible to have installed our first system at a world leading research site twelve months to the day after the formation of Cerca. This is all down to the incredible hard work and effort by the team. It has been amazing to work with such talented and motivated people and I am excited to move forward with the next challenge, which is the move to clinical approval for the device as part of the treatment pathway for epilepsy. To be involved with this groundbreaking device which has the ability to improve the lives of so many children with neurological conditions is extraordinary.”

David Woolger, CEO of Cerca Magnetics

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